Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema

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Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema

Systemic thrombolysis with the recombinant tissue plasminogen activator (rtPA) is an effective therapy option in the treatment of acute ischaemic stroke [1]. A rare but potentially fatal side effect is the development of an orolingual angioedema [2]. Because of improvements in acute stroke therapy and an aging population the incidence of recurrent strokes is increasing and results in more patie...

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Refractory Angioedema in a Patient with Systemic Lupus Erythematosus

Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported.In lupus patients, angioedema may be the result of an ac...

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Hyperacute ischemic stroke without lesions on diffusion-weighted imaging in a patient treated with rtPA thrombolysis

KEY CLINICAL MESSAGE We report a comatose patient with severe neurological deficits who was without spontaneous language or movement. He had a good response to recombinant tissue plasminogen activator (rtPA) thrombolysis even though there were no detectable lesions on diffusion-weighted imaging (DWI). DWI is very sensitive for diagnosing hyperacute ischemic stroke, and rtPA thrombolysis is the ...

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refractory angioedema in a patient with systemic lupus erythematosus

angioedema secondary to c1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. a genetic defect of c1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported. in lupus patients, angioedema may be the result of an a...

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Cerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis.

BACKGROUND To investigate whether there is: (1) a specific temporal course of cerebral dysautoregulation in acute ischemic stroke, and (2) a separate detrimental effect of recombinant tissue plasminogen activator (rtPA) on autoregulation dynamics in this situation. METHODS We studied 16 patients with acute middle cerebral artery (MCA) occlusion and rtPA thrombolysis (intra-arterial or intrave...

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ژورنال

عنوان ژورنال: eNeurologicalSci

سال: 2017

ISSN: 2405-6502

DOI: 10.1016/j.ensci.2017.08.002